Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

Christina A. von Roemeling; Thomas R. Caulfield; Laura Marlow; Ilah Bok; Jiang Wen; James L. Miller; Robert Hughes; Lori Hazlehurst; Anthony B. Pinkerton; Derek C. Radisky; Han W. Tun; Yon Son Betty Kim; Amy L. Lane; John A. Copland

doi:10.18632/oncotarget.21545

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

Christina A. von Roemeling
, Thomas R. Caulfield
, Laura Marlow
, Ilah Bok
, Jiang Wen
, James L. Miller
, Robert Hughes
, Lori Hazlehurst
, Anthony B. Pinkerton
, Derek C. Radisky
, Han W. Tun
, Yon Son Betty Kim
, Amy L. Lane
, John A. Copland

Chemistry and Biochemistry

Center for the Science of Health Care Delivery
University of North Florida

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3-20
Number of pages	18
Journal	Oncotarget
Volume	9
Issue number	1
DOIs	https://doi.org/10.18632/oncotarget.21545
State	Published - 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus Subject Areas

Oncology

Keywords

Cancer
Drug discovery
High throughput drug screening
Lipid metabolism
Stearoyl CoA desaturase

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10.18632/oncotarget.21545

Cite this

von Roemeling, C. A., Caulfield, T. R., Marlow, L., Bok, I., Wen, J., Miller, J. L., Hughes, R., Hazlehurst, L., Pinkerton, A. B., Radisky, D. C., Tun, H. W., Kim, Y. S. B., Lane, A. L., & Copland, J. A. (2018). Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy. Oncotarget, 9(1), 3-20. https://doi.org/10.18632/oncotarget.21545

von Roemeling, CA, Caulfield, TR, Marlow, L, Bok, I, Wen, J, Miller, JL, Hughes, R, Hazlehurst, L, Pinkerton, AB, Radisky, DC, Tun, HW, Kim, YSB, Lane, AL & Copland, JA 2018, 'Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy', Oncotarget, vol. 9, no. 1, pp. 3-20. https://doi.org/10.18632/oncotarget.21545

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title = "Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy",

keywords = "Cancer, Drug discovery, High throughput drug screening, Lipid metabolism, Stearoyl CoA desaturase",

author = "\{von Roemeling\}, \{Christina A.\} and Caulfield, \{Thomas R.\} and Laura Marlow and Ilah Bok and Jiang Wen and Miller, \{James L.\} and Robert Hughes and Lori Hazlehurst and Pinkerton, \{Anthony B.\} and Radisky, \{Derek C.\} and Tun, \{Han W.\} and Kim, \{Yon Son Betty\} and Lane, \{Amy L.\} and Copland, \{John A.\}",

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year = "2018",

doi = "10.18632/oncotarget.21545",

language = "English",

volume = "9",

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AU - von Roemeling, Christina A.

AU - Caulfield, Thomas R.

AU - Marlow, Laura

AU - Bok, Ilah

AU - Wen, Jiang

AU - Miller, James L.

AU - Hughes, Robert

AU - Hazlehurst, Lori

AU - Pinkerton, Anthony B.

AU - Radisky, Derek C.

AU - Tun, Han W.

AU - Kim, Yon Son Betty

AU - Lane, Amy L.

AU - Copland, John A.

PY - 2018

Y1 - 2018

KW - Cancer

KW - Drug discovery

KW - High throughput drug screening

KW - Lipid metabolism

KW - Stearoyl CoA desaturase

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UR - https://www.scopus.com/pages/publications/85040547548#tab=citedBy

U2 - 10.18632/oncotarget.21545

DO - 10.18632/oncotarget.21545

M3 - Article

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AN - SCOPUS:85040547548

VL - 9

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JO - Oncotarget

JF - Oncotarget

IS - 1

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Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

UN SDGs

ASJC Scopus Subject Areas

Keywords

Access to Document

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