Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial

Alex Luedtke; Youyi Fong; Lars van der Laan; Fei Heng; Ying Huang; Yiwen Lu; Chenchen Yu; Lindsay N. Carpp; Sanne Roels; Mathieu Le Gars; Griet A. Van Roey; Daniel J. Stieh; Ilse Van Dromme; Avi Kenny; Marco Carone; Ollivier Hyrien; Victor Ayala; Lakshmi Jayashankar; Flora Castellino; Obrimpong Amoa-Awua; Manjula Basappa; Britta Flach; Bob C. Lin; Christopher Moore; Mursal Naisan; Muhammed Naqvi; Sandeep Narpala; Sarah O'Connell; Allen Mueller; Leo Serebryannyy; Mike Castro; Jennifer Wang; Gabrielle Dziubla; April K. Randhawa; Michele P. Andrasik; Jenny Hendriks; Carla Truyers; Frank Struyf; Hanneke Schuitemaker; Macaya Douoguih; James G. Kublin; Lawrence Corey; Kathleen M. Neuzil; Linda Gail Bekker; Nigel Garrett; Sandra W. Cardoso; Patrice DelaFontaine; Craig A. Magaret; Johan Vingerhoets; Martin Casapia; Marcelo H. Losso; Susan J. Little; Aditya Gaur; Edith Swann; Christos J. Petropoulos; Adrian B. McDermott; Jerald Sadoff; Glenda E. Gray; Beatriz Grinsztejn; Paul A. Goepfert; Dean Follmann; Pavitra Roychoudhury; Alexander L. Greninger; Richard A. Koup; Ruben O. Donis; Peter B. Gilbert

doi:10.1016/j.isci.2025.113660

Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial

Alex Luedtke
, Youyi Fong
, Lars van der Laan
, Fei Heng
, Ying Huang
, Yiwen Lu
, Chenchen Yu
, Lindsay N. Carpp
, Sanne Roels
, Mathieu Le Gars
, Griet A. Van Roey
, Daniel J. Stieh
, Ilse Van Dromme
, Avi Kenny
, Marco Carone
, Ollivier Hyrien
, Victor Ayala
, Lakshmi Jayashankar
, Flora Castellino
, Obrimpong Amoa-Awua

Manjula Basappa, Britta Flach, Bob C. Lin, Christopher Moore, Mursal Naisan, Muhammed Naqvi, Sandeep Narpala, Sarah O'Connell, Allen Mueller, Leo Serebryannyy, Mike Castro, Jennifer Wang, Gabrielle Dziubla, April K. Randhawa, Michele P. Andrasik, Jenny Hendriks, Carla Truyers, Frank Struyf, Hanneke Schuitemaker, Macaya Douoguih, James G. Kublin, Lawrence Corey, Kathleen M. Neuzil, Linda Gail Bekker, Nigel Garrett, Sandra W. Cardoso, Patrice DelaFontaine, Craig A. Magaret, Johan Vingerhoets, Martin Casapia, Marcelo H. Losso, Susan J. Little, Aditya Gaur, Edith Swann, Christos J. Petropoulos, Adrian B. McDermott, Jerald Sadoff, Glenda E. Gray, Beatriz Grinsztejn, Paul A. Goepfert, Dean Follmann, Pavitra Roychoudhury, Alexander L. Greninger, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert

Mathematics and Statistics

University of Washington
Duke University School of Medicine
University of Cape Town
University of KwaZulu-Natal
University of California, San Diego
St. Jude Children's Research Hospital

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	113660
Pages (from-to)	113660
Journal	iScience
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/j.isci.2025.113660
State	Published - Nov 21 2025

ASJC Scopus Subject Areas

General

Keywords

Immune response
Immunology

Access to Document

10.1016/j.isci.2025.113660

Cite this

Luedtke, A., Fong, Y., van der Laan, L., Heng, F., Huang, Y., Lu, Y., Yu, C., Carpp, L. N., Roels, S., Le Gars, M., Van Roey, G. A., Stieh, D. J., Van Dromme, I., Kenny, A., Carone, M., Hyrien, O., Ayala, V., Jayashankar, L., Castellino, F., ... Gilbert, P. B. (2025). Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial. iScience, 28(11), 113660. Article 113660. https://doi.org/10.1016/j.isci.2025.113660

Luedtke, A, Fong, Y, van der Laan, L, Heng, F, Huang, Y, Lu, Y, Yu, C, Carpp, LN, Roels, S, Le Gars, M, Van Roey, GA, Stieh, DJ, Van Dromme, I, Kenny, A, Carone, M, Hyrien, O, Ayala, V, Jayashankar, L, Castellino, F, Amoa-Awua, O, Basappa, M, Flach, B, Lin, BC, Moore, C, Naisan, M, Naqvi, M, Narpala, S, O'Connell, S, Mueller, A, Serebryannyy, L, Castro, M, Wang, J, Dziubla, G, Randhawa, AK, Andrasik, MP, Hendriks, J, Truyers, C, Struyf, F, Schuitemaker, H, Douoguih, M, Kublin, JG, Corey, L, Neuzil, KM, Bekker, LG, Garrett, N, Cardoso, SW, DelaFontaine, P, Magaret, CA, Vingerhoets, J, Casapia, M, Losso, MH, Little, SJ, Gaur, A, Swann, E, Petropoulos, CJ, McDermott, AB, Sadoff, J, Gray, GE, Grinsztejn, B, Goepfert, PA, Follmann, D, Roychoudhury, P, Greninger, AL, Koup, RA, Donis, RO & Gilbert, PB 2025, 'Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial', iScience, vol. 28, no. 11, 113660, pp. 113660. https://doi.org/10.1016/j.isci.2025.113660

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title = "Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial",

keywords = "Immune response, Immunology",

author = "Alex Luedtke and Youyi Fong and \{van der Laan\}, Lars and Fei Heng and Ying Huang and Yiwen Lu and Chenchen Yu and Carpp, \{Lindsay N.\} and Sanne Roels and \{Le Gars\}, Mathieu and \{Van Roey\}, \{Griet A.\} and Stieh, \{Daniel J.\} and \{Van Dromme\}, Ilse and Avi Kenny and Marco Carone and Ollivier Hyrien and Victor Ayala and Lakshmi Jayashankar and Flora Castellino and Obrimpong Amoa-Awua and Manjula Basappa and Britta Flach and Lin, \{Bob C.\} and Christopher Moore and Mursal Naisan and Muhammed Naqvi and Sandeep Narpala and Sarah O'Connell and Allen Mueller and Leo Serebryannyy and Mike Castro and Jennifer Wang and Gabrielle Dziubla and Randhawa, \{April K.\} and Andrasik, \{Michele P.\} and Jenny Hendriks and Carla Truyers and Frank Struyf and Hanneke Schuitemaker and Macaya Douoguih and Kublin, \{James G.\} and Lawrence Corey and Neuzil, \{Kathleen M.\} and Bekker, \{Linda Gail\} and Nigel Garrett and Cardoso, \{Sandra W.\} and Patrice DelaFontaine and Magaret, \{Craig A.\} and Johan Vingerhoets and Martin Casapia and Losso, \{Marcelo H.\} and Little, \{Susan J.\} and Aditya Gaur and Edith Swann and Petropoulos, \{Christos J.\} and McDermott, \{Adrian B.\} and Jerald Sadoff and Gray, \{Glenda E.\} and Beatriz Grinsztejn and Goepfert, \{Paul A.\} and Dean Follmann and Pavitra Roychoudhury and Greninger, \{Alexander L.\} and Koup, \{Richard A.\} and Donis, \{Ruben O.\} and Gilbert, \{Peter B.\}",

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AU - Fong, Youyi

AU - van der Laan, Lars

AU - Heng, Fei

AU - Huang, Ying

AU - Lu, Yiwen

AU - Yu, Chenchen

AU - Carpp, Lindsay N.

AU - Roels, Sanne

AU - Le Gars, Mathieu

AU - Van Roey, Griet A.

AU - Stieh, Daniel J.

AU - Van Dromme, Ilse

AU - Kenny, Avi

AU - Carone, Marco

AU - Hyrien, Ollivier

AU - Ayala, Victor

AU - Jayashankar, Lakshmi

AU - Castellino, Flora

AU - Amoa-Awua, Obrimpong

AU - Basappa, Manjula

AU - Flach, Britta

AU - Lin, Bob C.

AU - Moore, Christopher

AU - Naisan, Mursal

AU - Naqvi, Muhammed

AU - Narpala, Sandeep

AU - O'Connell, Sarah

AU - Mueller, Allen

AU - Serebryannyy, Leo

AU - Castro, Mike

AU - Wang, Jennifer

AU - Dziubla, Gabrielle

AU - Randhawa, April K.

AU - Andrasik, Michele P.

AU - Hendriks, Jenny

AU - Truyers, Carla

AU - Struyf, Frank

AU - Schuitemaker, Hanneke

AU - Douoguih, Macaya

AU - Kublin, James G.

AU - Corey, Lawrence

AU - Neuzil, Kathleen M.

AU - Bekker, Linda Gail

AU - Garrett, Nigel

AU - Cardoso, Sandra W.

AU - DelaFontaine, Patrice

AU - Magaret, Craig A.

AU - Vingerhoets, Johan

AU - Casapia, Martin

AU - Losso, Marcelo H.

AU - Little, Susan J.

AU - Gaur, Aditya

AU - Swann, Edith

AU - Petropoulos, Christos J.

AU - McDermott, Adrian B.

AU - Sadoff, Jerald

AU - Gray, Glenda E.

AU - Grinsztejn, Beatriz

AU - Goepfert, Paul A.

AU - Follmann, Dean

AU - Roychoudhury, Pavitra

AU - Greninger, Alexander L.

AU - Koup, Richard A.

AU - Donis, Ruben O.

AU - Gilbert, Peter B.

PY - 2025/11/21

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Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial

ASJC Scopus Subject Areas

Keywords

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