Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity

Samer O. Abdul-Hay; Amy L. Lane; Thomas R. Caulfield; Clémence Claussin; Juliette Bertrand; Amandine Masson; Shakeel Choudhry; Abdul H. Fauq; Guhlam M. Maharvi; Malcolm A. Leissring

doi:10.1021/jm301280p

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity

Samer O. Abdul-Hay, Amy L. Lane, Thomas R. Caulfield, Clémence Claussin, Juliette Bertrand, Amandine Masson, Shakeel Choudhry, Abdul H. Fauq, Guhlam M. Maharvi, Malcolm A. Leissring

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2246-2255
Number of pages	10
Journal	Journal of Medicinal Chemistry
Volume	56
Issue number	6
DOIs	https://doi.org/10.1021/jm301280p
State	Published - Mar 28 2013

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

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10.1021/jm301280p

Cite this

@article{b7e7a264701f42c2912bbb777892a892,

title = "Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity",

author = "Abdul-Hay, {Samer O.} and Lane, {Amy L.} and Caulfield, {Thomas R.} and Cl{\'e}mence Claussin and Juliette Bertrand and Amandine Masson and Shakeel Choudhry and Fauq, {Abdul H.} and Maharvi, {Guhlam M.} and Leissring, {Malcolm A.}",

year = "2013",

month = mar,

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doi = "10.1021/jm301280p",

language = "English",

volume = "56",

pages = "2246--2255",

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T1 - Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity

AU - Abdul-Hay, Samer O.

AU - Lane, Amy L.

AU - Caulfield, Thomas R.

AU - Claussin, Clémence

AU - Bertrand, Juliette

AU - Masson, Amandine

AU - Choudhry, Shakeel

AU - Fauq, Abdul H.

AU - Maharvi, Guhlam M.

AU - Leissring, Malcolm A.

PY - 2013/3/28

Y1 - 2013/3/28

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U2 - 10.1021/jm301280p

DO - 10.1021/jm301280p

M3 - Article

C2 - 23437776

AN - SCOPUS:84875750447

SN - 0022-2623

VL - 56

SP - 2246

EP - 2255

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 6

ER -

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity

ASJC Scopus Subject Areas

Access to Document

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