Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features

Craig A. Magaret; Li Li; Allan C. deCamp; Morgane Rolland; Michal Juraska; Brian D. Williamson; James Ludwig; Cindy Molitor; David Benkeser; Alex Luedtke; Brian Simpkins; Fei Heng; Yanqing Sun; Lindsay N. Carpp; Hongjun Bai; Bethany L. Dearlove; Elena E. Giorgi; Mandy Jongeneelen; Boerries Brandenburg; Matthew McCallum; John E. Bowen; David Veesler; Jerald Sadoff; Glenda E. Gray; Sanne Roels; An Vandebosch; Daniel J. Stieh; Mathieu Le Gars; Johan Vingerhoets; Beatriz Grinsztejn; Paul A. Goepfert; Leonardo Paiva de Sousa; Mayara Secco Torres Silva; Martin Casapia; Marcelo H. Losso; Susan J. Little; Aditya Gaur; Linda Gail Bekker; Nigel Garrett; Carla Truyers; Ilse Van Dromme; Edith Swann; Mary A. Marovich; Dean Follmann; Kathleen M. Neuzil; Lawrence Corey; Alexander L. Greninger; Pavitra Roychoudhury; Ollivier Hyrien; Peter B. Gilbert

doi:10.1038/s41467-024-46536-w

Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features

Craig A. Magaret, Li Li, Allan C. deCamp, Morgane Rolland, Michal Juraska, Brian D. Williamson, James Ludwig, Cindy Molitor, David Benkeser, Alex Luedtke, Brian Simpkins, Fei Heng, Yanqing Sun, Lindsay N. Carpp, Hongjun Bai, Bethany L. Dearlove, Elena E. Giorgi, Mandy Jongeneelen, Boerries Brandenburg, Matthew McCallumJohn E. Bowen, David Veesler, Jerald Sadoff, Glenda E. Gray, Sanne Roels, An Vandebosch, Daniel J. Stieh, Mathieu Le Gars, Johan Vingerhoets, Beatriz Grinsztejn, Paul A. Goepfert, Leonardo Paiva de Sousa, Mayara Secco Torres Silva, Martin Casapia, Marcelo H. Losso, Susan J. Little, Aditya Gaur, Linda Gail Bekker, Nigel Garrett, Carla Truyers, Ilse Van Dromme, Edith Swann, Mary A. Marovich, Dean Follmann, Kathleen M. Neuzil, Lawrence Corey, Alexander L. Greninger, Pavitra Roychoudhury, Ollivier Hyrien, Peter B. Gilbert

Mathematics and Statistics

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	2175
Pages (from-to)	2175
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-46536-w
State	Published - Dec 2024

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

Keywords

Humans
Ad26COVS1
COVID-19/prevention & control
SARS-CoV-2
Vaccine Efficacy
Amino Acids
Antibodies, Viral
Antibodies, Neutralizing

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10.1038/s41467-024-46536-w

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Magaret, C. A., Li, L., deCamp, A. C., Rolland, M., Juraska, M., Williamson, B. D., Ludwig, J., Molitor, C., Benkeser, D., Luedtke, A., Simpkins, B., Heng, F., Sun, Y., Carpp, L. N., Bai, H., Dearlove, B. L., Giorgi, E. E., Jongeneelen, M., Brandenburg, B., ... Gilbert, P. B. (2024). Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nature Communications, 15(1), 2175. Article 2175. https://doi.org/10.1038/s41467-024-46536-w

Magaret, CA, Li, L, deCamp, AC, Rolland, M, Juraska, M, Williamson, BD, Ludwig, J, Molitor, C, Benkeser, D, Luedtke, A, Simpkins, B, Heng, F, Sun, Y, Carpp, LN, Bai, H, Dearlove, BL, Giorgi, EE, Jongeneelen, M, Brandenburg, B, McCallum, M, Bowen, JE, Veesler, D, Sadoff, J, Gray, GE, Roels, S, Vandebosch, A, Stieh, DJ, Le Gars, M, Vingerhoets, J, Grinsztejn, B, Goepfert, PA, de Sousa, LP, Silva, MST, Casapia, M, Losso, MH, Little, SJ, Gaur, A, Bekker, LG, Garrett, N, Truyers, C, Van Dromme, I, Swann, E, Marovich, MA, Follmann, D, Neuzil, KM, Corey, L, Greninger, AL, Roychoudhury, P, Hyrien, O & Gilbert, PB 2024, 'Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features', Nature Communications, vol. 15, no. 1, 2175, pp. 2175. https://doi.org/10.1038/s41467-024-46536-w

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AU - Juraska, Michal

AU - Williamson, Brian D.

AU - Ludwig, James

AU - Molitor, Cindy

AU - Benkeser, David

AU - Luedtke, Alex

AU - Simpkins, Brian

AU - Heng, Fei

AU - Sun, Yanqing

AU - Carpp, Lindsay N.

AU - Bai, Hongjun

AU - Dearlove, Bethany L.

AU - Giorgi, Elena E.

AU - Jongeneelen, Mandy

AU - Brandenburg, Boerries

AU - McCallum, Matthew

AU - Bowen, John E.

AU - Veesler, David

AU - Sadoff, Jerald

AU - Gray, Glenda E.

AU - Roels, Sanne

AU - Vandebosch, An

AU - Stieh, Daniel J.

AU - Le Gars, Mathieu

AU - Vingerhoets, Johan

AU - Grinsztejn, Beatriz

AU - Goepfert, Paul A.

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AU - Silva, Mayara Secco Torres

AU - Casapia, Martin

AU - Losso, Marcelo H.

AU - Little, Susan J.

AU - Gaur, Aditya

AU - Bekker, Linda Gail

AU - Garrett, Nigel

AU - Truyers, Carla

AU - Van Dromme, Ilse

AU - Swann, Edith

AU - Marovich, Mary A.

AU - Follmann, Dean

AU - Neuzil, Kathleen M.

AU - Corey, Lawrence

AU - Greninger, Alexander L.

AU - Roychoudhury, Pavitra

AU - Hyrien, Ollivier

AU - Gilbert, Peter B.

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KW - Antibodies, Neutralizing

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Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features

ASJC Scopus Subject Areas

Keywords

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