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Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ

  • Elena J. Ciesielska
  • , Shalom Kim
  • , Hyacintha ghislaine M. Bisimwa
  • , Cody Grier
  • , Md Mostafijur Rahman
  • , Carolyn K.J. Young
  • , Matthew J. Young
  • , Marcos T. Oliveira
  • , Grzegorz L. Ciesielski
  • São Paulo State University (UNESP)

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Pages (from-to)147-158
Number of pages12
JournalMitochondrion
Volume61
DOIs
StatePublished - Nov 2021
Externally publishedYes

ASJC Scopus Subject Areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

Keywords

  • Antiviral nucleoside analogues
  • COVID-19
  • DNA polymerase gamma
  • Mitochondrial DNA
  • Remdesivir

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