Simulated space radiation exposure leads to long-term changes in molecular signatures of the heart

Mollie A. Brekker; Maya Semel; Ivan Korostenskij; Osanna Krikourian; Kaelyn M.W. Kelly; Julia Santos; Moniece Lowe; Siddhita Mhatre; Janani Iyer; Amber M. Paul; Stephanie Puukila; Joshua S. Alwood; Yasaman Shirazi-Fard; Linda Rubinstein; David Goukassian; April E. Ronca; Candice G.T. Tahimic

doi:10.1016/j.lssr.2026.04.012

Simulated space radiation exposure leads to long-term changes in molecular signatures of the heart

Mollie A. Brekker
, Maya Semel
, Ivan Korostenskij
, Osanna Krikourian
, Kaelyn M.W. Kelly
, Julia Santos
, Moniece Lowe
, Siddhita Mhatre
, Janani Iyer
, Amber M. Paul
, Stephanie Puukila
, Joshua S. Alwood
, Yasaman Shirazi-Fard
, Linda Rubinstein
, David Goukassian
, April E. Ronca
, Candice G.T. Tahimic

Biology

NASA Ames Research Center
Universities Space Research Association
Embry-Riddle Aeronautical University
Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Life Sciences in Space Research
DOIs	https://doi.org/10.1016/j.lssr.2026.04.012
State	Accepted/In press - 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus Subject Areas

Radiation
Ecology
Astronomy and Astrophysics
Agricultural and Biological Sciences (miscellaneous)
Health, Toxicology and Mutagenesis

Keywords

Heart
Ionizing radiation
Mitochondria
Space radiation
Spaceflight
Transcriptomics

Access to Document

10.1016/j.lssr.2026.04.012

Cite this

Brekker, M. A., Semel, M., Korostenskij, I., Krikourian, O., Kelly, K. M. W., Santos, J., Lowe, M., Mhatre, S., Iyer, J., Paul, A. M., Puukila, S., Alwood, J. S., Shirazi-Fard, Y., Rubinstein, L., Goukassian, D., Ronca, A. E., & Tahimic, C. G. T. (Accepted/In press). Simulated space radiation exposure leads to long-term changes in molecular signatures of the heart. Life Sciences in Space Research. https://doi.org/10.1016/j.lssr.2026.04.012

Brekker, MA, Semel, M, Korostenskij, I, Krikourian, O, Kelly, KMW, Santos, J, Lowe, M, Mhatre, S, Iyer, J, Paul, AM, Puukila, S, Alwood, JS, Shirazi-Fard, Y, Rubinstein, L, Goukassian, D, Ronca, AE & Tahimic, CGT 2026, 'Simulated space radiation exposure leads to long-term changes in molecular signatures of the heart', Life Sciences in Space Research. https://doi.org/10.1016/j.lssr.2026.04.012

@article{e4b5267051ff49658f801a53426b10f9,

title = "Simulated space radiation exposure leads to long-term changes in molecular signatures of the heart",

keywords = "Heart, Ionizing radiation, Mitochondria, Space radiation, Spaceflight, Transcriptomics",

author = "Brekker, \{Mollie A.\} and Maya Semel and Ivan Korostenskij and Osanna Krikourian and Kelly, \{Kaelyn M.W.\} and Julia Santos and Moniece Lowe and Siddhita Mhatre and Janani Iyer and Paul, \{Amber M.\} and Stephanie Puukila and Alwood, \{Joshua S.\} and Yasaman Shirazi-Fard and Linda Rubinstein and David Goukassian and Ronca, \{April E.\} and Tahimic, \{Candice G.T.\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s).",

year = "2026",

doi = "10.1016/j.lssr.2026.04.012",

language = "English",

}

TY - JOUR

T1 - Simulated space radiation exposure leads to long-term changes in molecular signatures of the heart

AU - Brekker, Mollie A.

AU - Semel, Maya

AU - Korostenskij, Ivan

AU - Krikourian, Osanna

AU - Kelly, Kaelyn M.W.

AU - Santos, Julia

AU - Lowe, Moniece

AU - Mhatre, Siddhita

AU - Iyer, Janani

AU - Paul, Amber M.

AU - Puukila, Stephanie

AU - Alwood, Joshua S.

AU - Shirazi-Fard, Yasaman

AU - Rubinstein, Linda

AU - Goukassian, David

AU - Ronca, April E.

AU - Tahimic, Candice G.T.

PY - 2026

Y1 - 2026

KW - Heart

KW - Ionizing radiation

KW - Mitochondria

KW - Space radiation

KW - Spaceflight

KW - Transcriptomics

UR - https://www.scopus.com/pages/publications/105044374905

UR - https://www.scopus.com/pages/publications/105044374905#tab=citedBy

U2 - 10.1016/j.lssr.2026.04.012

DO - 10.1016/j.lssr.2026.04.012

M3 - Article

AN - SCOPUS:105044374905

SN - 2214-5524

JO - Life Sciences in Space Research

JF - Life Sciences in Space Research

ER -

Simulated space radiation exposure leads to long-term changes in molecular signatures of the heart

UN SDGs

ASJC Scopus Subject Areas

Keywords

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