The development of N-α-(2-carboxyl)benzoyl- N 5-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Corey P. Causey; Justin E. Jones; Jessica L. Slack; Daisuke Kamei; Larry E. Jones; Venkataraman Subramanian; Bryan Knuckley; Pedram Ebrahimi; Alexander A. Chumanevich; Yuan Luo; Hiroshi Hashimoto; Mamoru Sato; Lorne J. Hofseth; Paul R. Thompson

doi:10.1021/jm2008985

The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Corey P. Causey
, Justin E. Jones
, Jessica L. Slack
, Daisuke Kamei
, Larry E. Jones
, Venkataraman Subramanian
, Bryan Knuckley
, Pedram Ebrahimi
, Alexander A. Chumanevich
, Yuan Luo
, Hiroshi Hashimoto
, Mamoru Sato
, Lorne J. Hofseth
, Paul R. Thompson

University of South Carolina

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	6919-6935
Number of pages	17
Journal	Journal of Medicinal Chemistry
Volume	54
Issue number	19
DOIs	https://doi.org/10.1021/jm2008985
State	Published - Oct 13 2011
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

Access to Document

10.1021/jm2008985

Cite this

Causey, C. P., Jones, J. E., Slack, J. L., Kamei, D., Jones, L. E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A. A., Luo, Y., Hashimoto, H., Sato, M., Hofseth, L. J., & Thompson, P. R. (2011). The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry, 54(19), 6919-6935. https://doi.org/10.1021/jm2008985

The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. / Causey, Corey P.; Jones, Justin E.; Slack, Jessica L. et al.
In: Journal of Medicinal Chemistry, Vol. 54, No. 19, 13.10.2011, p. 6919-6935.

Research output: Contribution to journal › Article › peer-review

Causey, CP, Jones, JE, Slack, JL, Kamei, D, Jones, LE, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, AA, Luo, Y, Hashimoto, H, Sato, M, Hofseth, LJ & Thompson, PR 2011, 'The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors', Journal of Medicinal Chemistry, vol. 54, no. 19, pp. 6919-6935. https://doi.org/10.1021/jm2008985

Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V et al. The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry. 2011 Oct 13;54(19):6919-6935. doi: 10.1021/jm2008985

Causey, Corey P. ; Jones, Justin E. ; Slack, Jessica L. et al. / The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. In: Journal of Medicinal Chemistry. 2011 ; Vol. 54, No. 19. pp. 6919-6935.

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title = "The development of N-α-(2-carboxyl)benzoyl- N 5-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors",

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AU - Jones, Justin E.

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AU - Kamei, Daisuke

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AU - Subramanian, Venkataraman

AU - Knuckley, Bryan

AU - Ebrahimi, Pedram

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AU - Luo, Yuan

AU - Hashimoto, Hiroshi

AU - Sato, Mamoru

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AU - Thompson, Paul R.

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The development of N-α-(2-carboxyl)benzoyl- N 5-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

ASJC Scopus Subject Areas

Access to Document

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Cite this

The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors