The development of N-α-(2-carboxyl)benzoyl- N 5-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Corey P. Causey; Justin E. Jones; Jessica L. Slack; Daisuke Kamei; Larry E. Jones; Venkataraman Subramanian; Bryan Knuckley; Pedram Ebrahimi; Alexander A. Chumanevich; Yuan Luo; Hiroshi Hashimoto; Mamoru Sato; Lorne J. Hofseth; Paul R. Thompson

doi:10.1021/jm2008985

The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Corey P. Causey
, Justin E. Jones
, Jessica L. Slack
, Daisuke Kamei
, Larry E. Jones
, Venkataraman Subramanian
, Bryan Knuckley
, Pedram Ebrahimi
, Alexander A. Chumanevich
, Yuan Luo
, Hiroshi Hashimoto
, Mamoru Sato
, Lorne J. Hofseth
, Paul R. Thompson

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	6919-6935
Number of pages	17
Journal	Journal of Medicinal Chemistry
Volume	54
Issue number	19
DOIs	https://doi.org/10.1021/jm2008985
State	Published - Oct 13 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

Access to Document

10.1021/jm2008985

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Causey, C. P., Jones, J. E., Slack, J. L., Kamei, D., Jones, L. E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A. A., Luo, Y., Hashimoto, H., Sato, M., Hofseth, L. J., & Thompson, P. R. (2011). The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry, 54(19), 6919-6935. https://doi.org/10.1021/jm2008985

The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. / Causey, Corey P.; Jones, Justin E.; Slack, Jessica L. et al.
In: Journal of Medicinal Chemistry, Vol. 54, No. 19, 13.10.2011, p. 6919-6935.

Research output: Contribution to journal › Article › peer-review

Causey, CP, Jones, JE, Slack, JL, Kamei, D, Jones, LE, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, AA, Luo, Y, Hashimoto, H, Sato, M, Hofseth, LJ & Thompson, PR 2011, 'The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors', Journal of Medicinal Chemistry, vol. 54, no. 19, pp. 6919-6935. https://doi.org/10.1021/jm2008985

Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V et al. The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry. 2011 Oct 13;54(19):6919-6935. doi: 10.1021/jm2008985

Causey, Corey P. ; Jones, Justin E. ; Slack, Jessica L. et al. / The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. In: Journal of Medicinal Chemistry. 2011 ; Vol. 54, No. 19. pp. 6919-6935.

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AU - Hashimoto, Hiroshi

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