The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

Tina M. Sawatzky; Sarah A. Mann; Jordan Shauna Tucker; Aida A. Bibart; Corey P. Causey; Bryan Knuckley

doi:10.3390/biom15111494

The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

Tina M. Sawatzky
, Sarah A. Mann
, Jordan Shauna Tucker
, Aida A. Bibart
, Corey P. Causey
, Bryan Knuckley

Chemistry and Biochemistry

University of North Florida

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	1494
Journal	Biomolecules
Volume	15
Issue number	11
DOIs	https://doi.org/10.3390/biom15111494
State	Published - Sep 23 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Amino Acid Sequence
Arginine/metabolism
Enzyme Inhibitors/pharmacology
Humans
Kinetics
Methylation
Peptide Library
Peptides/chemistry
Protein Processing, Post-Translational
Protein-Arginine N-Methyltransferases/antagonists & inhibitors
Repressor Proteins/antagonists & inhibitors
Substrate Specificity

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10.3390/biom15111494

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title = "The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay",

keywords = "Amino Acid Sequence, Arginine/metabolism, Enzyme Inhibitors/pharmacology, Humans, Kinetics, Methylation, Peptide Library, Peptides/chemistry, Protein Processing, Post-Translational, Protein-Arginine N-Methyltransferases/antagonists \& inhibitors, Repressor Proteins/antagonists \& inhibitors, Substrate Specificity",

author = "Sawatzky, \{Tina M.\} and Mann, \{Sarah A.\} and Tucker, \{Jordan Shauna\} and Bibart, \{Aida A.\} and Causey, \{Corey P.\} and Bryan Knuckley",

note = "Publisher Copyright: {\textcopyright} 2025 by the authors.",

year = "2025",

month = sep,

day = "23",

doi = "10.3390/biom15111494",

language = "English",

volume = "15",

number = "11",

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T1 - The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

AU - Sawatzky, Tina M.

AU - Mann, Sarah A.

AU - Tucker, Jordan Shauna

AU - Bibart, Aida A.

AU - Causey, Corey P.

AU - Knuckley, Bryan

PY - 2025/9/23

Y1 - 2025/9/23

KW - Amino Acid Sequence

KW - Arginine/metabolism

KW - Enzyme Inhibitors/pharmacology

KW - Humans

KW - Kinetics

KW - Methylation

KW - Peptide Library

KW - Peptides/chemistry

KW - Protein Processing, Post-Translational

KW - Protein-Arginine N-Methyltransferases/antagonists & inhibitors

KW - Repressor Proteins/antagonists & inhibitors

KW - Substrate Specificity

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UR - https://www.scopus.com/pages/publications/105023072810#tab=citedBy

UR - https://www.mendeley.com/catalogue/c69c9bd9-47d0-308b-b447-fb78b080923a/

U2 - 10.3390/biom15111494

DO - 10.3390/biom15111494

M3 - Article

C2 - 41301411

AN - SCOPUS:105023072810

VL - 15

JO - Biomolecules

JF - Biomolecules

IS - 11

M1 - 1494

ER -

The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

UN SDGs

Keywords

Access to Document

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