Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage

Jordan L. Chirumbolo; Amanda Hutsell; Amar Kosovac; Isabella Ihemis; Melissa J. Whitford; Juliane Nguy; Rowan J. Wolf; Damir Sarajlic; Topher Hunter; Matthew F. Myntti; Terri N. Ellis

doi:10.1128/spectrum.00243-26

Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage

Jordan L. Chirumbolo
, Amanda Hutsell
, Amar Kosovac
, Isabella Ihemis
, Melissa J. Whitford
, Juliane Nguy
, Rowan J. Wolf
, Damir Sarajlic
, Topher Hunter
, Matthew F. Myntti
, Terri N. Ellis

Biology

Producción científica: Article › revisión exhaustiva

Idioma original	English
Páginas (desde-hasta)	e0024326
Publicación	Microbiology Spectrum
Volumen	14
N.º	8
DOI	https://doi.org/10.1128/spectrum.00243-26
Estado	Published - ago 4 2026

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus Subject Areas

Physiology
Ecology
Genetics
General Immunology and Microbiology
Cell Biology
Microbiology (medical)
Infectious Diseases

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10.1128/spectrum.00243-26

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Chirumbolo, J. L., Hutsell, A., Kosovac, A., Ihemis, I., Whitford, M. J., Nguy, J., Wolf, R. J., Sarajlic, D., Hunter, T., Myntti, M. F., & Ellis, T. N. (2026). Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage. Microbiology Spectrum , 14(8), e0024326. https://doi.org/10.1128/spectrum.00243-26

Chirumbolo, JL, Hutsell, A, Kosovac, A, Ihemis, I, Whitford, MJ, Nguy, J, Wolf, RJ, Sarajlic, D, Hunter, T, Myntti, MF & Ellis, TN 2026, 'Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage', Microbiology Spectrum , vol. 14, n.º 8, pp. e0024326. https://doi.org/10.1128/spectrum.00243-26

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title = "Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage",

keywords = "antibiotic resistance, antibiotic tolerance, Klebsiella, porins, Porins/genetics, Bacterial Outer Membrane Proteins/genetics, Biofilms/drug effects, Humans, Klebsiella Infections/microbiology, Drug Resistance, Bacterial, Klebsiella pneumoniae/drug effects, Acids/pharmacology, Anti-Bacterial Agents/pharmacology, Escherichia coli/drug effects, Microbial Sensitivity Tests, Staphylococcus aureus/drug effects, Hydrogen-Ion Concentration",

author = "Chirumbolo, \{Jordan L.\} and Amanda Hutsell and Amar Kosovac and Isabella Ihemis and Whitford, \{Melissa J.\} and Juliane Nguy and Wolf, \{Rowan J.\} and Damir Sarajlic and Topher Hunter and Myntti, \{Matthew F.\} and Ellis, \{Terri N.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2026 Chirumbolo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",

year = "2026",

month = aug,

day = "4",

doi = "10.1128/spectrum.00243-26",

language = "English",

volume = "14",

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TY - JOUR

T1 - Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage

AU - Chirumbolo, Jordan L.

AU - Hutsell, Amanda

AU - Kosovac, Amar

AU - Ihemis, Isabella

AU - Whitford, Melissa J.

AU - Nguy, Juliane

AU - Wolf, Rowan J.

AU - Sarajlic, Damir

AU - Hunter, Topher

AU - Myntti, Matthew F.

AU - Ellis, Terri N.

PY - 2026/8/4

Y1 - 2026/8/4

KW - antibiotic resistance

KW - antibiotic tolerance

KW - Klebsiella

KW - porins

KW - Porins/genetics

KW - Bacterial Outer Membrane Proteins/genetics

KW - Biofilms/drug effects

KW - Humans

KW - Klebsiella Infections/microbiology

KW - Drug Resistance, Bacterial

KW - Klebsiella pneumoniae/drug effects

KW - Acids/pharmacology

KW - Anti-Bacterial Agents/pharmacology

KW - Escherichia coli/drug effects

KW - Microbial Sensitivity Tests

KW - Staphylococcus aureus/drug effects

KW - Hydrogen-Ion Concentration

UR - https://www.scopus.com/pages/publications/105046761759

UR - https://www.scopus.com/pages/publications/105046761759#tab=citedBy

U2 - 10.1128/spectrum.00243-26

DO - 10.1128/spectrum.00243-26

M3 - Article

C2 - 42461018

AN - SCOPUS:105046761759

VL - 14

SP - e0024326

JO - Microbiology Spectrum

JF - Microbiology Spectrum

IS - 8

ER -

Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage

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ASJC Scopus Subject Areas

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