The development of N-α-(2-carboxyl)benzoyl- N 5-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Corey P. Causey; Justin E. Jones; Jessica L. Slack; Daisuke Kamei; Larry E. Jones; Venkataraman Subramanian; Bryan Knuckley; Pedram Ebrahimi; Alexander A. Chumanevich; Yuan Luo; Hiroshi Hashimoto; Mamoru Sato; Lorne J. Hofseth; Paul R. Thompson

doi:10.1021/jm2008985

The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Corey P. Causey, Justin E. Jones, Jessica L. Slack, Daisuke Kamei, Larry E. Jones, Venkataraman Subramanian, Bryan Knuckley, Pedram Ebrahimi, Alexander A. Chumanevich, Yuan Luo, Hiroshi Hashimoto, Mamoru Sato, Lorne J. Hofseth, Paul R. Thompson

University of South Carolina

Producción científica: Article › revisión exhaustiva

Idioma original	English
Páginas (desde-hasta)	6919-6935
Número de páginas	17
Publicación	Journal of Medicinal Chemistry
Volumen	54
N.º	19
DOI	https://doi.org/10.1021/jm2008985
Estado	Published - oct 13 2011
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

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10.1021/jm2008985

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Causey, C. P., Jones, J. E., Slack, J. L., Kamei, D., Jones, L. E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A. A., Luo, Y., Hashimoto, H., Sato, M., Hofseth, L. J., & Thompson, P. R. (2011). The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry, 54(19), 6919-6935. https://doi.org/10.1021/jm2008985

The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. / Causey, Corey P.; Jones, Justin E.; Slack, Jessica L. et al.
En: Journal of Medicinal Chemistry, Vol. 54, N.º 19, 13.10.2011, p. 6919-6935.

Producción científica: Article › revisión exhaustiva

Causey, CP, Jones, JE, Slack, JL, Kamei, D, Jones, LE, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, AA, Luo, Y, Hashimoto, H, Sato, M, Hofseth, LJ & Thompson, PR 2011, 'The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors', Journal of Medicinal Chemistry, vol. 54, n.º 19, pp. 6919-6935. https://doi.org/10.1021/jm2008985

Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V et al. The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry. 2011 oct 13;54(19):6919-6935. doi: 10.1021/jm2008985

Causey, Corey P. ; Jones, Justin E. ; Slack, Jessica L. et al. / The development of N-α-(2-carboxyl)benzoyl- N ⁵-(2-fluoro- 1-iminoethyl)- l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N⁵-(2-chloro-1-iminoethyl)-l-ornithine amide (o -Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. En: Journal of Medicinal Chemistry. 2011 ; Vol. 54, N.º 19. pp. 6919-6935.

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