The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

Tina M. Sawatzky; Sarah A. Mann; Jordan Shauna Tucker; Aida A. Bibart; Corey P. Causey; Bryan Knuckley

doi:10.3390/biom15111494

The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

Tina M. Sawatzky
, Sarah A. Mann
, Jordan Shauna Tucker
, Aida A. Bibart
, Corey P. Causey
, Bryan Knuckley

Chemistry and Biochemistry

University of North Florida

Producción científica: Article › revisión exhaustiva

Idioma original	English
Número de artículo	1494
Publicación	Biomolecules
Volumen	15
N.º	11
DOI	https://doi.org/10.3390/biom15111494
Estado	Published - sept 23 2025

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title = "The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay",

keywords = "Amino Acid Sequence, Arginine/metabolism, Enzyme Inhibitors/pharmacology, Humans, Kinetics, Methylation, Peptide Library, Peptides/chemistry, Protein Processing, Post-Translational, Protein-Arginine N-Methyltransferases/antagonists \& inhibitors, Repressor Proteins/antagonists \& inhibitors, Substrate Specificity",

author = "Sawatzky, \{Tina M.\} and Mann, \{Sarah A.\} and Tucker, \{Jordan Shauna\} and Bibart, \{Aida A.\} and Causey, \{Corey P.\} and Bryan Knuckley",

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AU - Tucker, Jordan Shauna

AU - Bibart, Aida A.

AU - Causey, Corey P.

AU - Knuckley, Bryan

PY - 2025/9/23

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KW - Amino Acid Sequence

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KW - Enzyme Inhibitors/pharmacology

KW - Humans

KW - Kinetics

KW - Methylation

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KW - Peptides/chemistry

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KW - Protein-Arginine N-Methyltransferases/antagonists & inhibitors

KW - Repressor Proteins/antagonists & inhibitors

KW - Substrate Specificity

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The Identification of a Sub-Micromolar Peptide-Based Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor from a Plate-Based Screening Assay

ODS de las Naciones Unidas

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